Synthesis, identification of some new 1,2,4-triazole derivatives from 6-amino-1,3-dimethyluracil and evaluation of their molecular docking, Anti-oxidant and experimental

The present work includes synthesis of new series heterocyclic derivatives containing 6-amino-1,3-dimethyl uracil moiety linked to 1,2,4-triazole [6-8 and 10]. first way reaction 6-amino-1,3-dimethyluracil with ethyl chloroacetate K2CO3 as catalyst in DMF solvent gives ester derivative [1]. Then, compound [1] was converted into (semicarbazide, thiosemicarbazide, phenylsemicarbazide hydrazide derivatives) a result the hydrazine hydrate) corresponding [2-5] respectively. Cyclization alkaline media (4N-NaOH) give compounds [6-8] While, Compound [5] cyclization by CS2 (20% KOH) [9] that reacted directly hydrate 1,3,4-triazole [10]. synthesized were identified spectral methods their [FTIR some them 1HNMR, 13C-NMR] measurements its physical properties specific testes. All screened for vitro antioxidant studies 2,2-diphenyl-1-picrylhydrazyl (DPPH) phosphomolybdenum methods. Among bioactive molecules [1-10] exhibited promising activity compared standard drug Ascorbic acid.